Nature Materials

Applied immunology

Article | 19 August 2019

Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

Imbalance of the gut microbiome has been implicated in numerous human diseases. Nanoparticles have now been designed to target colitis by modulating the gut microbiome, local innate immune response and restoration of the intestinal barrier function.
- Yonghyun Lee
- , Kohei Sugihara
- & James J. Moon
Letter | 05 March 2018

A facile approach to enhance antigen response for personalized cancer vaccination

A strategy to enhance antigen immunogenicity is shown using polyethyleneimine adsorbed on mesoporous silica microrod vaccine as a platform for neoantigens, supporting potent humoral immune response and inhibition of tumour growth following vaccination.
- Aileen Weiwei Li
- , Miguel C. Sobral
- & David J. Mooney

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