Analytical biochemistry

Analytical biochemistry is the study of biochemical components found in a cell or other biological sample. This scientific discipline uses a broad range of techniques for separation, identification, quantification and functional characterization of biological molecules.

Latest Research and Reviews

News and Comment

  • Comments & Opinion
    | Open Access

    Proteins and peptides are amongst the most widely used research reagents but often their quality is inadequate and can result in poor data reproducibility. Here we propose a simple set of guidelines that, when correctly applied to protein reagents should provide more reliable experimental data.

    • Ario de Marco
    • , Nick Berrow
    •  & Bertrand Raynal
  • News & Views |

    The continuous monitoring of proteins is a current challenge in medical diagnostics. A new electrochemical approach aiming to address this has been described. The method uses antibodies as a recognition element to achieve the real-time measurement of proteins in saliva in the mouth.

    • Kevin J. Cash
    •  & Kevin W. Plaxco
    Nature Chemistry 13, 392-393
  • Editorial
    | Open Access

    Detecting clinically relevant diagnostic biomarkers, suitable for point-of-care detection, may facilitate rapid treatment and prevention of disease. However, medical diagnosis for which there are limited quantities of testable tissue or fluid, require point-of-care technologies with superior sensitivity and specificity. The purpose of this Editorial is to provide an overview of the Collection’s content, comprising original research into fluidics-based diagnostic platforms—specifically those made of paper or other low-cost materials, that can suitably operate with tiny sample volumes from mL to nL. In particular, we will focus on the clinical applications of such research, with potential uses in a number of fields including combating the COVID-19 pandemic for instance.

    • Chao-Min Cheng
    Scientific Reports 10, 14230