Research Highlights

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  • A recent study shows that chemotaxis shapes the microscale organization of the ocean’s microbiome.

    • Ashley York
    Research Highlight
  • A recent study shows how tumour-resident intracellular bacteria enhance survival and the metastatic capacities of circulating tumour cells by protecting them from mechanical stress.

    • Adrian Gonzalez Lopez
    Research Highlight
  • This study shows that although colistin resistance in Klebsiella pneumoniae is associated with a fitness defect in gut colonization, it increases bacterial survival outside the host, thus enabling efficient host-to-host transmission.

    • Andrea Du Toit
    Research Highlight
  • This study reports that Listeria monocytogenes interferes with a cell death pathway involved in cell-mediated immunity to promote neuroinvasion and persistence.

    • Andrea Du Toit
    Research Highlight
  • A recent study uncovered a new family of Enterococcus pore-forming toxins that use human leukocyte antigen class I or major histocompatibility complex class I as receptors.

    • Ashley York
    Research Highlight
  • A recent study provides evidence of non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-associated anosmia.

    • Ashley York
    Research Highlight
  • Two recent papers implicate Epstein–Barr virus (EBV) as a trigger for the development of multiple sclerosis and provide mechanistic insights into EBV-mediated development of the disease.

    • Andrea Du Toit
    Research Highlight
  • A recent study found that constituents of the gut virome are negatively associated with seroconversion following rotavirus vaccination, possibly explaining the diminished effectiveness of rotavirus vaccines in low- and middle-income countries.

    • Ashley York
    Research Highlight
  • Recent studies provide new insights into the regulation of lysogeny and prophage induction.

    • Andrea Du Toit
    Research Highlight
  • A recent study finds that upregulation of nutrient-permeable channels in the parasitophorous vacuole membrane increases the acquisition of amino acids by artemisinin-resistant parasites to compensate for fitness costs.

    • Ashley York
    Research Highlight
  • This study provides insights into the neuroinvasive mechanism of neurotropic alphaherpesviruses, which involves viral assimilation and repurposing of a cellular motor protein.

    • Andrea Du Toit
    Research Highlight
  • A recent study provides evidence that the extracellular DNA-based architecture of bacterial biofilms relies on the rare left-handed helical form of DNA known as Z-DNA.

    • Ashley York
    Research Highlight
  • This study shows that segmented filamentous bacteria provide early protection against Citrobacter rodentium via a microbially derived metabolite that primes host innate immunity.

    • Andrea Du Toit
    Research Highlight
  • Two recent studies provide mechanistic evidence that members of the microbiota cooperate to confer colonization resistance against pathogens.

    • Ashley York
    Research Highlight
  • The authors of this study designed a novel therapeutic class of antimicrobials in which they optimized drug binding and permeation of the drug through bacterial membrane transporters simultaneously.

    • Megan Cully
    Research Highlight
  • This study shows that gut bacteria accumulate host-targeted drugs intracellularly, which affects the therapeutic effect of the drug as well as metabolite secretion of the accumulating bacteria without much having an impact on bacterial growth.

    • Andrea Du Toit
    Research Highlight
  • This study demonstrates that commensal bacteria and fungi have opposing roles in the responses of tumours to radiotherapy.

    • Anna Dart
    Research Highlight
  • A recent study finds that the gut microbiota generates diurnal rhythms in innate immune responses that synchronize with host feeding rhythms in mice, allowing the host to anticipate exposure to pathogens.

    • Ashley York
    Research Highlight
  • This study shows that co-existence of the four Lactobacillus species in the gut of the honey bee is mainly dependent on the pollen-rich diet of the host, and mediated by the specialization of the gut symbionts towards distinct pollen-derived nutrients.

    • Andrea Du Toit
    Research Highlight
  • This study reports that bacteriocins are encoded in temperate phages, and that they can be transferred between bacterial hosts, which provides a competitive advantage.

    • Andrea Du Toit
    Research Highlight