Life and death in the soil microbiome: how ecological processes influence biogeochemistry

  • Noah W. Sokol
  • Eric Slessarev
  • Jennifer Pett-Ridge
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    • Bacteriophages are obligate parasites of their bacterial hosts; nevertheless, on a population level, phage–bacterium interactions can have beneficial outcomes. In this Review, Shkoporov, Turkington and Hill discuss the evidence for such mutualistic interactions in the gut microbiota and their roles.

      • Andrey N. Shkoporov
      • Christopher J. Turkington
      • Colin Hill
      Review Article
    • Trace metals are essential micronutrients required for survival across all kingdoms of life. In this Review, Murdoch and Skaar discuss the strategies whereby vertebrate hosts limit metal or induce excess metal to prevent bacterial proliferation, a process termed nutritional immunity, and they discuss adaptive mechanisms that bacterial pathogens have evolved to survive in conditions of metal depletion or excess.

      • Caitlin C. Murdoch
      • Eric P. Skaar
      Review Article
    • Marine biofilms grow on diverse marine surfaces, ranging from particles to animals and ships. In this Review, Qian and colleagues discuss the diversity and composition of marine biofilms and their role in the development of marine benthos and biofouling.

      • Pei-Yuan Qian
      • Aifang Cheng
      • Rui Zhang
      Review Article
    • CRISPR–Cas systems provide resistance against foreign mobile genetic elements and have a wide range of genome editing and biotechnological applications. In this Review, Wang, Pausch and Doudna examine recent advances in understanding the molecular structures and mechanisms of enzymes comprising bacterial RNA-guided CRISPR–Cas immune systems and deployed for wide-ranging genome editing applications.

      • Joy Y. Wang
      • Patrick Pausch
      • Jennifer A. Doudna
      Review Article
    • The anti-tuberculosis drug candidate pipeline is promising, but the recent breakthroughs are challenged with the need to prioritize drug combinations for clinical trials and revamping trial designs to accelerate regimen development. In this Review, Dartois and Rubin explore treatment challenges, drug development priorities, and approaches — from basic research to preclinical evaluation — that lead to the selection of drug combinations earlier in the discovery cascade to accelerate the approval of shorter treatment regimens.

      • Véronique A. Dartois
      • Eric J. Rubin
      Review Article
  • A recent study uncovered the geographical origins of the Black Death pandemic, offering a new perspective on the phylogenetic polytomy that served as a foundation for the expansion of Yersinia pestis across Eurasia and North Africa more than 600 years ago.

    • Adrian Gonzalez Lopez
    Research Highlight
  • A microfluidics study shows that bacterial biofilms form wrinkles when they grow and detach from a solid surface.

    • Ursula Hofer
    In Brief
  • Two recent studies highlight the potential of broadly neutralizing monoclonal antibodies for the long-term control of HIV in the absence of antiretroviral therapy.

    • Ashley York
    Research Highlight
  • A single-cell microfluidics study shows that phenotypic heterogeneity and fast growth can reduce antibiotic susceptibility.

    • Ursula Hofer
    In Brief
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The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has led to substantial disease and millions of deaths worldwide, with devastating socio-economic impacts. This Series contains articles from Nature Reviews Microbiology that explore the basic biology, epidemiology, emergence, evolution and pathogenesis of SARS-CoV-2 and pathogenic coronaviruses, as well as options for the control and prevention of COVID-19.
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