Diversity and evolution of the animal virome

  • Erin Harvey
  • Edward C. Holmes
Review Article

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    • CRISPR–Cas systems provide resistance against foreign mobile genetic elements and have a wide range of genome editing and biotechnological applications. In this Review, Wang, Pausch and Doudna examine recent advances in understanding the molecular structures and mechanisms of enzymes comprising bacterial RNA-guided CRISPR–Cas immune systems and deployed for wide-ranging genome editing applications.

      • Joy Y. Wang
      • Patrick Pausch
      • Jennifer A. Doudna
      Review Article
    • The anti-tuberculosis drug candidate pipeline is promising, but the recent breakthroughs are challenged with the need to prioritize drug combinations for clinical trials and revamping trial designs to accelerate regimen development. In this Review, Dartois and Rubin explore treatment challenges, drug development priorities, and approaches — from basic research to preclinical evaluation — that lead to the selection of drug combinations earlier in the discovery cascade to accelerate the approval of shorter treatment regimens.

      • Véronique A. Dartois
      • Eric J. Rubin
      Review Article
    • In this Review, Greening and Grinter describe the microorganisms and enzymes that use atmospheric trace gases, including hydrogen, carbon monoxide and methane, during growth and survival. They highlight important ecological and biogeochemical roles for these processes in diverse environments, including ecosystem resilience under changing conditions.

      • Chris Greening
      • Rhys Grinter
      Review Article
    • In this Review, Aldridge and colleagues describe different types of mycobacterial heterogeneity and discuss how cell-to-cell heterogeneity and environmental heterogeneity are generated and regulated in response to environmental cues.

      • Eun Seon Chung
      • William C. Johnson
      • Bree B. Aldridge
      Review Article
    • In this Review, Lamers and Haagmans explore recent clinical and experimental advances in understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis, interactions with host cells and the involvement of the immune system in the development of severe disease. Specifically, they focus on mechanisms underlying the development of COVID-19-associated acute respiratory distress syndrome.

      • Mart M. Lamers
      • Bart L. Haagmans
      Review Article
  • A study looking at the Tibetan Plateau finds that microbial shifts might contribute to irreversible soil degradation.

    • Ursula Hofer
    In Brief
  • This study used engineered bacteria to record the transcriptional responses of transiting bacteria in the gut environment.

    • Ursula Hofer
    In Brief
  • A study in mice shows that antibiotic treatment predisposes to invasive fungal infection through gut dysbiosis and barrier dysfunction.

    • Ursula Hofer
    In Brief
  • This Genome Watch highlights recently reported methods that enable genome editing of microorganisms within phylogenetically diverse communities.

    • Susannah G. Tringe
    Genome Watch
  • This Genome Watch highlights how metagenomics can fill the knowledge gap of the wild avian gut microbiome and enable the early detection of antibiotic-resistant bacteria with implications for public health policy and conservation management.

    • Physilia Ying Shi Chua
    • Jacob Agerbo Rasmussen
    Genome Watch
  • A recent study shows that chemotaxis shapes the microscale organization of the ocean’s microbiome.

    • Ashley York
    Research Highlight
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The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has led to substantial disease and millions of deaths worldwide, with devastating socio-economic impacts. This Series contains articles from Nature Reviews Microbiology that explore the basic biology, epidemiology, emergence, evolution and pathogenesis of SARS-CoV-2 and pathogenic coronaviruses, as well as options for the control and prevention of COVID-19.
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