Research Highlights

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  • As part of our Women in Immunology series, this article pays tribute to Lydia Rabinowitsch-Kempner, who is remembered not only for her work on tuberculosis and public health but also as an advocate for women’s rights.

    • Stefan H. E. Kaufmann
    Research Highlight
  • A newly identified pregnancy-specific deacetylation of maternal antibodies expands their ability to vertically transmit protection against intracellular infection in neonates.

    • Kirsty Minton
    Research Highlight
  • Lymph node colonization by tumour cells promotes subsequent spread to distant tissues by inducing broad alterations in tumour immunity and generating tumour-specific immune tolerance.

    • Lucy Bird
    Research Highlight
  • FlipFlop mice, in which the coreceptor proteins encoded by the Cd4 and Cd8 loci are reversed, shed light on the importance of T cell receptor signal length versus signal strength in determining helper versus cytotoxic T cell lineage fates.

    • Kirsty Minton
    Research Highlight
  • Epigenetic rewiring of bone marrow progenitor cells as a result of one inflammatory disease can enhance susceptibility to a distinct disease.

    • Yvonne Bordon
    Research Highlight
  • A newly described subset of innate-like lymphocytes with cytotoxic capabilities is shown to have an important role in cancer immunosurveillance. This cell population is broadly self-reactive, has a unique ontogeny and gains cytotoxic potential on sensing IL-15 in tumours.

    • Lucy Bird
    Research Highlight
  • Clusters of quiescent cancer cells in triple-negative breast cancer create an immunosuppressive microenvironment that might contribute to immunotherapy resistance and tumour recurrence.

    • Kirsty Minton
    Research Highlight
  • B cells signal to bone marrow niche cells via the neurotransmitter acetylcholine, curtailing immune cell production in the steady state and limiting the supply of inflammatory myeloid cells in cardiovascular disease.

    • Lucy Bird
    Research Highlight
  • Two papers in Science Immunology describe a role for tuft cells in the gallbladder and bile ducts in sensing bacteria and their products ascending from the small intestine to stimulate antibacterial immune responses.

    • Kirsty Minton
    Research Highlight
  • A bispecific molecule consisting of a PD1 antibody fused to a multimeric ligand for the costimulatory molecule GITR shows promising results in preclinical studies of solid tumours.

    • Alexandra Flemming
    Research Highlight
  • Steady-state sensing of Skint1 on keratinocytes by the γδ T cell receptor on dendritic epidermal T cells (DETCs) maintains DETCs in a poised state ready to respond to subsequent distress signals and restore epithelial homeostasis.

    • Lucy Bird
    Research Highlight
  • The accumulation of misfolded or otherwise unwanted proteins in a cell, known as proteotoxic stress, triggers an inflammatory response. This study describes a role for PKR as the sensor of protein accumulation, which triggers an innate immune response and helps to restore homeostasis.

    • Kirsty Minton
    Research Highlight
  • T cells need magnesium to function efficiently. They sense it via the cell surface integrin LFA-1, which triggers outside-in signalling to augment T cell effector functions against infection or cancers.

    • Lucy Bird
    Research Highlight