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  • The Omicron variant of SARS-CoV-2 has been reported to cause milder disease in adults but lead to increased hospital admissions in children. How can we compare disease severity in Omicron and Delta infections, and how should differences be interpreted?

    • Alex Sigal
    • Ron Milo
    • Waasila Jassat
  • In this Comment article, Gregory Poland and Richard Kennedy outline the importance of continued funding and infrastructure support for research into vaccine safety to inform public health decisions and increase public trust in new vaccine technologies.

    • Gregory A. Poland
    • Richard B. Kennedy
  • In this Comment article, Nisreen Alwan discusses what her experience as both a public health academic and a person living with Long COVID has taught her about the importance of including those with lived experience of a condition in setting the research agenda.

    • Nisreen A. Alwan
  • Mathematical models have been used to guide strategies for COVID-19 vaccine distribution. But with the emergence of new SARS-CoV-2 variants and waning immunity, how should vaccine distribution be prioritized?

    • Caroline E. Wagner
    • Chadi M. Saad-Roy
    • Bryan T. Grenfell
  • In this Comment article, Florent Ginhoux, Martin Guilliams and Miriam Merad call for a revised nomenclature of the dendritic cell (DC) lineage to distinguish between DC subsets and DC states and resolve confusion in the light of single-cell transcriptional profiling results.

    • Florent Ginhoux
    • Martin Guilliams
    • Miriam Merad
  • Black In Immuno harnesses social media and digital platforms to connect Black immunologists with one another and with the rest of the scientific ecosystem. We invite you to join us, to connect with and amplify Black immunologists, and to contribute to creating a more inclusive and innovative biomedical community.

    • Joel Babdor
    • Amy C. Fan
    • Elaine Kouame
  • Here, John Kelton and colleagues provide an overview of vaccine-induced immune thrombotic thrombocytopenia (VITT), a very rare complication that has been observed following vaccination with adenoviral vector-based COVID-19 vaccines.

    • John Greenhow Kelton
    • Donald Mitchell Arnold
    • Ishac Nazy
  • This Comment article proposes that T cell-oriented vaccine strategies should be considered to control the COVID-19 pandemic in the longer term, given declining levels of neutralizing antibodies with time after vaccination or infection and the emergence of viral escape variants.

    • Ji Yun Noh
    • Hye Won Jeong
    • Eui-Cheol Shin
  • It took roughly 1 year for a COVID-19 vaccine to become available, yet, four decades after the first patient with HIV was described, we do not yet have a vaccine for HIV. Here, Barton Haynes examines the biological reasons why vaccine development for HIV is so exceptionally challenging.

    • Barton F. Haynes
  • In this Comment article, Sofonias Tessema and John Nkengasong provide an overview of the current state of the COVID-19 pandemic in Africa and the challenges posed by the triple burden of emerging, endemic and non-communicable diseases.

    • Sofonias K. Tessema
    • John N. Nkengasong
  • The identification of elevated IL-6 levels in patients with severe COVID-19 led to the rapid development of clinical trials targeting this cytokine. Overall, these trials do not support the widespread use of IL-6 antagonists in hospitalized patients with mild-to-moderate disease, but IL-6 antagonists may be beneficial when rapidly deployed in patients with severe COVID-19, as we discuss here.

    • Simon A. Jones
    • Christopher A. Hunter
  • This Comment outlines how the recently licensed vaccines for COVID-19 activate innate immune mechanisms to promote immune memory to SARS-CoV-2. The authors also consider future challenges that could limit vaccine efficacy.

    • John R. Teijaro
    • Donna L. Farber
  • Reassuring data from accidental pregnancies that have occurred in the clinical trials of approved COVID-19 vaccines indicate that vaccination does not harm fertility or increase the rate of miscarriage.

    • Victoria Male
  • The COVID-19 pandemic has stressed the importance of understanding species such as bats that can serve as reservoirs for emerging viral threats. Here, Wang and colleagues call for greater consensus among the bat immunology community in five key areas.

    • Lin-Fa Wang
    • Akshamal M. Gamage
    • Emma C. Teeling