Research Highlights

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  • Crist et al. set out to investigate what makes the colonization of skeletal muscle by disseminated tumour cells (DTCs) so rare and found that this niche enforces persistent oxidative stress on DTCs that cannot be overcome and therefore, restrains their proliferation.

    • Anna Dart
    Research Highlight
  • Lv, Liu, Mo and colleagues demonstrate that in pancreatic ductal adenocarcinoma cells, gasdermin E transports the transcription factor YBX1 to the nucleus, where it promotes the expression of mucins, thereby providing tumour cells with a barrier against digestive enzymes.

    • Lucia Brunello
    Research Highlight
  • Guan, Polesso, Wang, et al. report that androgen receptor blockade, in addition to androgen deprivation therapy, enhances the response of T cells to anti-PD1 immune checkpoint inhibitors.

    • Lucia Brunello
    Research Highlight
  • North, Benbarche et al. engineered synthetic introns that were spliced specifically in cancer cells expressing the mutant spliceosome factor SF3B1. This led to expression of herpes simplex virus-thymidine kinase and vulnerability of cancer cells to treatment with the antiviral drug ganciclovir.

    • Ulrike Harjes
    Research Highlight
  • Nolan et al. used a mouse model of acute radiation exposure to reveal that radiotherapy can create a pro-metastatic lung microenvironment, an effect mediated by neutrophils.

    • Anna Dart
    Research Highlight
  • Kobayashi et al. describe a role for silent mutations in creating functional KRAS-Q61K and develop a strategy that could potentially target this mutant as well as other RAS-Q61X mutations.

    • Sarah Seton-Rogers
    Research Highlight
  • Asrir et al. show that tumour-associated high endothelial venues (TA-HEVs) in tumour-bearing mice are points of entry for lymphocytes, and increasing TA-HEVs frequency and maturation improves immune checkpoint blockade.

    • Ulrike Harjes
    Research Highlight
  • Kerdidani et al. have identified MHC-II-expressing cancer-associated fibroblasts in non-small-cell lung cancers where they appear to promote anti-tumour immunity.

    • Anna Dart
    Research Highlight
  • Yang, Zhang, Luan et al. report that a germline variant that increases the risk of Philadelphia chromosome-like acute lymphoblastic leukaemia upregulates GATA3 expression, which changes chromatin accessibility to allow activation of oncogenic pathways.

    • Sarah Seton-Rogers
    Research Highlight
  • Somasundara, Moss, Feigman et al. show that γδ natural killer T-like (NKT) cells expand during the late stages of pregnancy in mice because of changes in mammary epithelial cell surface protein expression, which was associated with suppressed mammary oncogenesis induced by BRCA1 loss or MYC-overexpression.

    • Ulrike Harjes
    Research Highlight
  • Vincze et al. have provided definitive evidence for the validity of Peto’s paradox by analysing cancer incidence in the largest study of mammal species to date.

    • Anna Dart
    Research Highlight
  • Thandapani et al. examined the role for tRNA biogenesis in T cell acute lymphoblastic leukaemia (T-ALL), and found that T-ALL cells are sensitive to valine tRNA levels, which could be exploited therapeutically by dietary valine restriction.

    • Sarah Seton-Rogers
    Research Highlight
  • Nie et al. performed metabolomics profiling on samples obtained from patients during the development of invasive lung adenocarcinoma and showed that metabolic pathways are progressively disrupted.

    • Anna Dart
    Research Highlight
  • Hung, Yost, Xie et al. show that extrachromosomal DNAs (ecDNAs) are held together in hubs in the nucleus and that intermolecular interactions between ecDNAs can enhance oncogene expression.

    • Sarah Seton-Rogers
    Research Highlight
  • Li, Xiao and colleagues show that antihistamines might increase the efficacy of immune checkpoint blockade.

    • Megan Cully
    Research Highlight
  • Klemm et al. examined the role of tumour-associated macrophages (TAMs) at different stages of brain metastasis in mouse models and found that targeting TAMs by inhibiting both CSF1R and STAT5 might have long-lasting efficacy and prevent resistance.

    • Sarah Seton-Rogers
    Research Highlight
  • Pernigoni et al. present a unique mode of non-genetic resistance accounting for castration-resistant prostate cancer that is mediated by androgen-synthesizing gut microbiota.

    • Anna Dart
    Research Highlight
  • Neuhöfer et al. have identified a rare subpopulation of pancreatic acinar cells in the exocrine compartment that renews the pancreas by fuelling clonal expansion. When harbouring Kras mutations, these acinar cells accelerated clone formation and might represent an early cancer precursor lesion.

    • Linda Gummlich
    Research Highlight
  • Canale et al. engineered the bacterial strain Escherichia coli Nissle 1917 to recycle ammonia into arginine, and showed synergistic responses with anti-programmed cell death 1 ligand 1 therapy in tumour-bearing mice when injected intratumourally or given systemically.

    • Ulrike Harjes
    Research Highlight