CRISPR in cancer biology and therapy

Alyna Katti, Bianca J. Diaz, Christina M. Caragine, Neville E. Sanjana & Lukas E. Dow

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    October 2021 marked the 20th anniversary of Nature Reviews Cancer. This Collection includes cutting-edge articles, including our anniversary issue contents, and thought-provoking commentaries and viewpoints. We also delve into our archives as a reminder of where the journal started and all that has been achieved in cancer research since the journal’s launch.

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    These Milestones celebrate two decades of breakthroughs in basic, translational and clinical research which have revolutionized our understanding and management of cancer.

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  • In this Tools of the Trade article, Yaara Oren describes the development and use of the Watermelon system to simultaneously track the lineage, transcriptional profile and proliferative state of each cancer cell in a population, which enables the characterization of rare cycling persister cells.

    • Yaara Oren
    Tools of the Trade
  • This month, Nature Reviews Cancer launches Tools of the Trade articles, in which early career researchers can discuss the methods or techniques that they use to conduct their research.

    Editorial
  • Crist et al. set out to investigate what makes the colonization of skeletal muscle by disseminated tumour cells (DTCs) so rare and found that this niche enforces persistent oxidative stress on DTCs that cannot be overcome and therefore, restrains their proliferation.

    • Anna Dart
    Research Highlight
  • In this Tools of the Trade article, Ana Luísa Correia describes the development and use of a tracker of dormant disseminated tumour cells to investigate the distribution and dynamics of dormant reservoirs within and across distant sites.

    • Ana Luísa Correia
    Tools of the Trade
  • Lv, Liu, Mo and colleagues demonstrate that in pancreatic ductal adenocarcinoma cells, gasdermin E transports the transcription factor YBX1 to the nucleus, where it promotes the expression of mucins, thereby providing tumour cells with a barrier against digestive enzymes.

    • Lucia Brunello
    Research Highlight
A triangle showing a human body in one corner, foods in one corner and cancer cells in the third corner, all connected by arrows as a cycle

Diet and systemic metabolism

This series of articles explores how changes in diet and systemic metabolism can influence tumour development and progression, how this is affected by the presence of metabolic disease and how we can use this knowledge to improve anticancer therapy.
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