Research Highlights

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  • The first single-cell transcriptome of the gastrulating human embryo.

    • Madhura Mukhopadhyay
    Research Highlight
  • Two microscopy approaches bring flexibility to mesoscopic imaging in the brain, allowing independent imaging in multiple regions simultaneously.

    • Nina Vogt
    Research Highlight
  • Two studies use nanopores for single-protein fingerprinting and make headway toward single-protein sequencing.

    • Rita Strack
    Research Highlight
  • Single-cell GET-seq (scGET-seq) enables the probing of compacted as well as accessible chromatin in single cells, covering a greater portion of the genome, which provides insights into genomic and epigenetic dynamics.

    • Lei Tang
    Research Highlight
  • Repair-seq enables efficient profiling of genetic factors involved in DNA double-strand break repair.

    • Lin Tang
    Research Highlight
  • A framework to reconstruct tissue architecture from imaging data.

    • Madhura Mukhopadhyay
    Research Highlight
  • Researchers identified a single-effector Cas, Cas7-11, that architecturally diverges from previous CRISPR single- or multi-component systems and can possess RNA knockdown activity without detectable collateral activity in mammalian cells.

    • Lei Tang
    Research Highlight
  • An artificial system models the mechanical properties of the tumor microenvironment in vitro.

    • Madhura Mukhopadhyay
    Research Highlight
  • Directed evolution of adeno-associated virus capsids with the DELIVER approach generates tissue-specific viruses.

    • Nina Vogt
    Research Highlight
  • Four independent research groups have used proximity ligation techniques to profile the in vivo mouse secretome.

    • Rita Strack
    Research Highlight
  • Reprogrammed natural killer cells show enhanced functional properties and anti-tumor efficacy.

    • Madhura Mukhopadhyay
    Research Highlight
  • A deep-learning-based tool and a large ground truth dataset enable spike inference from calcium imaging data acquired in a variety of experimental conditions.

    • Nina Vogt
    Research Highlight
  • Researchers have registered a gene expression atlas to a whole-body EM volume of a marine bristle worm.

    • Rita Strack
    Research Highlight
  • A software platform for analyzing data-independent acquisition (DIA) proteomics data.

    • Arunima Singh
    Research Highlight