LAG3 inhibits T cell activation, but exactly how it does so has been unclear given a lack of structural information. Here the authors provide the crystal structure of the human and mouse LAG3 ectodomains, showing how they interact with known ligands and antibodies.

Shi and colleagues describe a subset of erythroid precursors with immune characteristics that can be isolated from the yolk sac to the adult bone marrow stages during human ontogenesis.

Goldrath and colleagues define the diversity of gene expression and genome accessibility in mouse CD8⁺ T_RM cells in distinct tissues and identify molecules critical forgeneration of CD8⁺ T_RM cells in response to acute viral infection.

Lanzavecchia and colleagues use single-cell B cell receptor sequencing to examine the clonal structure, stability and dynamics of the B cell repertoire and the relationship between memory B cells and newly generated plasma cells in humans.

Abramson and colleagues show that Aire⁺MHCII⁺ ILC3s sense, internalize and present Candida albicans and modulate the induction of C. albicans-specific T_H17 cells.

LAG3 inhibits T cell activation, but exactly how it does so has been unclear given a lack of structural information. Here the authors provide the crystal structure of the human and mouse LAG3 ectodomains, showing how they interact with known ligands and antibodies.

Shi and colleagues describe a subset of erythroid precursors with immune characteristics that can be isolated from the yolk sac to the adult bone marrow stages during human ontogenesis.

Goldrath and colleagues define the diversity of gene expression and genome accessibility in mouse CD8⁺ T_RM cells in distinct tissues and identify molecules critical forgeneration of CD8⁺ T_RM cells in response to acute viral infection.

Lanzavecchia and colleagues use single-cell B cell receptor sequencing to examine the clonal structure, stability and dynamics of the B cell repertoire and the relationship between memory B cells and newly generated plasma cells in humans.

Skin T_reg cell crosstalk with hair-follicle stem cells (HFSCs) can control hair regrowth. Here the authors show that glucocorticoid receptor signaling in skin T_reg cells induces TGF-β3, which in turn facilitates HFSC proliferation.

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