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  • The benefit from immune checkpoint inhibitors is tempered by immunologic toxicities, which involve diverse organs, have varying biology, onset time, and severity. Herein, we identify important areas of controversy and open research questions in the field of immune-related toxicity.

    • Michael Conroy
    • Jarushka Naidoo
    Comment Open Access
  • Among the existing machine learning frameworks, reservoir computing demonstrates fast and low-cost training, and its suitability for implementation in various physical systems. This Comment reports on how aspects of reservoir computing can be applied to classical forecasting methods to accelerate the learning process, and highlights a new approach that makes the hardware implementation of traditional machine learning algorithms practicable in electronic and photonic systems.

    • Lina Jaurigue
    • Kathy Lüdge
    Comment Open Access
  • The protein corona is a key component controlling biological activity, that develops on foreign materials when introduced to biological environments. This comment discusses the risk of errors from poor methodology that can lead to misinterpretation and poor corona analysis which can impact diagnostic and clinical applications.

    • Morteza Mahmoudi
    Comment Open Access
  • Since its inception 10 years ago Nature Communications has strived to publish papers of high quality and relevance to communities of researchers across the whole of the natural sciences. In more recent years, we have happily seen an increase in the submission and publication of clinical research studies. To serve the clinical community to the best of our ability we have clarified our guide to authors on what we expect to see on submission of clinical research papers and we are launching a Clinical Collection that presents under one umbrella a selection of the interesting papers we have published in this area

    Editorial Open Access
  • The Trojan asteroids in Jupiter’s orbit have been preserved unaltered since the early ages of our Solar System. In October 2021, NASA launched its mission, Lucy, to visit and study these asteroids in order to learn more about the original building blocks that formed our planets.

    Editorial Open Access
  • Though the lunar samples returned by the Apollo and Luna missions have been studied for more than 50 years, scientists are discovering new clues into the early evolution of the Moon by looking through the lens of modern analytical techniques.

    • Tabb C. Prissel
    • Kelsey B. Prissel
    Comment Open Access
  • RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.

    • Xuexiang Han
    • Hanwen Zhang
    • Michael J. Mitchell
    Comment Open Access
  • While existing microbots display effective propulsion, their functionalities decrease dramatically upon decreasing the robot size. Accordingly, it is desired to customize microscale robots for their specific mission and body location. Selecting the microbot constituents with task-specific tailored functionalities will enhance their practicality in performing their primary mission.

    • Joseph Wang
    Comment Open Access
  • Discoveries of persistent coastal species in the open ocean shift our understanding of biogeographic barriers. Floating plastic debris from pollution now supports a novel sea surface community composed of coastal and oceanic species at sea that might portend significant ecological shifts in the marine environment.

    • Linsey E. Haram
    • James T. Carlton
    • Gregory M. Ruiz
    Comment Open Access
  • In this opinion piece, we discuss why computational tools to limit the identifiability of genomic data are a promising avenue for privacy-preservation and legal compliance. Even where these technologies do not eliminate all residual risk of individual identification, the law may still consider such data anonymised.

    • Alexander Bernier
    • Hanshi Liu
    • Bartha Maria Knoppers
    Comment Open Access
  • Developing more productive and sustainable crops will be essential to achieving food security in coming decades. A core process in plant evolution has been the transfer of chloroplast-encoded genes to the nuclear genome. We propose reverting this process as a new approach to improve plant disease resistance and photosynthesis in future crops.

    • Briardo Llorente
    • María Eugenia Segretin
    • Nicolás E. Blanco
    Comment Open Access
  • An outcome of phage infection, lateral transduction, has been shown to mobilize chromosomal genes between bacterial cells at rates that exceed those of mobile genetic elements such as plasmids. Does this mean that the bacterial chromosome should be considered a mobile genetic element?

    • James P. J. Hall
    Comment Open Access
  • While the technological revolution is accelerating, digital poverty is undermining the Sustainable Development Goals. This article introduces a justice-oriented digital framework which considers how fair access to digital capabilities, commodities, infrastructure, and governance can reduce global inequality and advance the SDGs.

    • Katriona O’Sullivan
    • Serena Clark
    • Malcolm MacLachlan
    Comment Open Access
  • The pandemic has caused disruption to many aspects of scientific research. In this Comment the authors describe the findings from surveys of scientists between April 2020 and January 2021, which suggests there was a decline in new projects started in that time.

    • Jian Gao
    • Yian Yin
    • Dashun Wang
    Comment Open Access
  • The logistical and practical challenges of supplying food for long-term space missions are substantial. In this comment, the authors discuss potential biotechnological approaches that could be used to aid the production of food crops in space.

    • Yongming Liu
    • Gengxin Xie
    • Maozhi Ren
    Comment Open Access
  • Single atom catalysts hold the potential to significantly impact the chemical and energy industrial sectors. This editorial introduces the state of the field along with a collection of Articles and Comments that encapsulate the ongoing efforts of the research community in this field.

    Editorial Open Access
  • Air pollution is a cause of disease for millions around the world and now more than ever urgent action is required to tackle the burden of its impacts. Doing so will not only improve both life expectancy and quality of life, but will also lead to a more just and sustainable world.

    Editorial Open Access