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Immunotherapy is useful for the treatment of some cancer types; however many cancer types do not respond to therapy and resistance can occur. This collection highlights immunotherapy research published in our journal.
This year Nature Communications has published original research and opinion across the Earth sciences. To celebrate these contributions, the editors of the Earth team select some of their highlights from the papers, commentary, reviews, perspectives and editorials published in 2021.
Nature Communications is interested in publishing high-quality clinical research in all areas of clinical medicine. In this collection, we highlight some of the latest clinical research papers published in the journal.
In this collection, we highlight papers reporting structural insights into amyloid fibrils associated with neurodegenerative and systemic diseases as well as functional amyloids that were obtained using cryo-electron microscopy (cryo-EM), NMR, X-ray crystallography and microcrystal electron diffraction. Cryo-EM also allows the structure determination of fibrils isolated from tissue samples, which revealed structural differences between ex vivo and in vitro generated fibrils and a wide spread polymorphism among amyloid fibrils.
Image: Marcus Fändrich; L. Radamaker, et al. Nat Commun 12, 875 (2021)
While proteomics approaches have facilitated the analysis of proteins present in cells and tissues, spatial proteomics have enabled the delineation of proteins’ spatial localization within cells, which has enhanced our understanding of their form and function.
This collection highlights the contributions of Electrospray Ionization and Orbitrap to the emergence of biological mass spectrometry, and the progress made in characterizing the human proteome in health and disease.
Four years ago, the NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Cell Census Network (BICCN) was launched, aiming to identify and catalog the diverse cells types in human, monkey and mouse brain.