Review Articles

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  • Structural metals enable improved energy efficiency through their reduced mass, higher thermal stability and better mechanical properties; here, methods of improving the sustainability of structural metals, from recycling to contaminant tolerance, are described.

    • Dierk Raabe
    • C. Cem Tasan
    • Elsa A. Olivetti
    Review Article
  • Genetic strategies for improving the yield and sustainability of agricultural crops, and the resilience of crops in the face of biotic and abiotic stresses contingent on projected climate change, are evaluated.

    • Julia Bailey-Serres
    • Jane E. Parker
    • Julian I. Schroeder
    Review Article
  • The processes that control the movement of carbon from microfossils on the seafloor to erupting volcanoes and deep diamonds, in a cycle driven by plate tectonics, are reviewed.

    • Terry Plank
    • Craig E. Manning
    Review Article
  • The authors review recent developments in our understanding of the antitumour effects of the innate immune system and how this system could be harnessed in the clinic.

    • Olivier Demaria
    • Stéphanie Cornen
    • Eric Vivier
    Review Article
  • Progress in integrating atomically thin two-dimensional materials with silicon-based technology is reviewed, together with the associated opportunities and challenges, and a roadmap for future applications is presented.

    • Deji Akinwande
    • Cedric Huyghebaert
    • Frank H. L. Koppens
    Review Article
  • Structural and microscopy studies of gene transcription underpin a model in which phosphorylation controls the shuttling of RNA polymerase II between promoter and gene-body condensates to regulate transcription initiation and elongation.

    • Patrick Cramer
    Review Article
  • Abiotic processes can mimic or alter the biogenic traces of early life but advances in micro- and nanoscale analyses provide evidence that—with geological contextualization—improves our ability to address this issue.

    • Emmanuelle J. Javaux
    Review Article
  • A Review of advances in memory-editing techniques in humans suggests that these techniques are advancing beyond science fiction and could hold promise for translation into clinical practice.

    • Elizabeth A. Phelps
    • Stefan G. Hofmann
    Review Article
  • The milestones that mark the advances in ageing research, the medical, commercial and societal implications of ageing and the different ageing pathways and processes that are associated with ageing are discussed.

    • Judith Campisi
    • Pankaj Kapahi
    • Eric Verdin
    Review Article
  • Understanding the behaviour of the machines powered by artificial intelligence that increasingly mediate our social, cultural, economic and political interactions is essential to our ability to control the actions of these intelligent machines, reap their benefits and minimize their harms.

    • Iyad Rahwan
    • Manuel Cebrian
    • Michael Wellman
    Review Article
  • The history and advancements of gravitational-wave astronomy are reviewed and the future of the field is discussed.

    • M. Coleman Miller
    • Nicolás Yunes
    Review Article
  • Combining mobile phone technologies with infectious disease diagnostics can increase patients’ access to testing and treatment and provide public health authorities with new ways to monitor and control outbreaks of infectious diseases.

    • Christopher S. Wood
    • Michael R. Thomas
    • Molly M. Stevens
    Review Article
  • The current state of the search for dark-matter particles is reviewed, and a broader experimental and theoretical approach is proposed to solve the dark-matter problem.

    • Gianfranco Bertone
    • Tim M. P. Tait
    Review Article
  • By analysing particle production in high-energy nuclear collisions, the phase boundary of strongly interacting matter is located and the phase structure of quantum chromodynamics is elucidated, implying quark–hadron duality.

    • Anton Andronic
    • Peter Braun-Munzinger
    • Johanna Stachel
    Review Article
  • Longer human lives have led to a global burden of late-life disease, and so interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health.

    • Linda Partridge
    • Joris Deelen
    • P. Eline Slagboom
    Review Article