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  • Integrating bio- and chemocatalysis in one-pot enabled new reaction pathways to amides with broad substrate scope and enantioselectivity under mild conditions, building towards more sustainable chemistry.

    • Colette Whitfield
    Research Highlight
  • No matter your career stage, pregnancy in the lab raises complex questions — and definitive answers are hard to come by. In conversation with members of Women in Supramolecular Chemistry (WISC), we share our experience, discuss research into the challenges and move the conversation to the support needed by people who are pregnant. We conclude that community is critical to improve experiences.

    • Anna Slater
    • Claudia Caltagirone
    • Jennifer Leigh
    Comment
  • A simple processing procedure enables the fabrication of biodegradable protein-based plastics with tunable properties.

    • Claire Ashworth
    Research Highlight
  • By understanding the magnetic properties of purely organic thin films, opportunities are presented to employ new characteristics in myriad applications.

    • Colette Whitfield
    Research Highlight
  • Glycosylation of proteins can stabilize folding intermediates and thus enable the total synthesis of correctly folded disulfide-rich proteins.

    • Stephen G. Davey
    Research Highlight
  • Advanced 17O NMR methods can help distinguish oxygen atoms from different hydrogen-bonding environments in glucose.

    • Stacey-Lynn Paiva
    Research Highlight
  • A review of Arieh Warshel’s autobiography, where he describes his life from childhood to when he fascinates about understanding the catalytic power of enzymes.

    • Shina Caroline Lynn Kamerlin
    Books & Arts
  • While there is much of the last two years we may wish to forget, it is imperative that we share our pandemic chemistry teaching experiences.

    • Maria Gallardo-Williams
    In the Classroom
  • A rearrangement reaction — a classic of traditional organic synthesis — has been applied to a polymer, enabling conversion of a polyester to a vinyl polymer.

    • Stephen G. Davey
    Research Highlight
  • Cyanuric acid (CA) derivatives can co-assemble with polyadenine sequences to form a triple helical DNA-based structure bearing functional groups able to guide higher ordered architectures.

    • Colette Whitfield
    Research Highlight
  • Using ammonium bicarbonate as an additive can boost the reactivity of amines with carbon dioxide in microdroplet reactions.

    • Stacey-Lynn Paiva
    Research Highlight
  • Climate change is a chemical problem and chemistry and chemical engineering can provide some of the solutions. What kind of chemistry should we be doing?

    • Anthony J. Ryan
    • Rachael H. Rothman
    Comment
  • The COVID-19 pandemic has had a dramatic impact on the way we do research. Here, I share an approach to rebuild research capacity in a new collaborative fashion termed ‘teamlets’. Teamlets enable a team-based approach to boost morale, increase data integrity, faciliate interdisciplinarity and ensure continuity of expertise.

    • Stefan Howorka
    Comment
  • Rapidly alternating the polarity of electrodes offers a new opportunity for synthetic chemists to obtain selective reaction outcomes in organic electrosynthesis.

    • Stephen G. Davey
    Research Highlight
  • A silicon-linker that tethers a diyne and a diynophile provides new mechanistic insight and control of hexadehydro-Diels–Alder (HDDA) reactions.

    • Colette Whitfield
    Research Highlight
  • Synthetic siderophore-antibiotic conjugates can afford promising antibiotic profiles against ESKAPE pathogens and unique resistant mechanisms.

    • Stacey-Lynn Paiva
    Research Highlight
  • The combination of mass spectroscopy-based proteomics with molecular dynamics enables the in-depth study of metallothioneine-Zn(II) binding mechanisms, critical to cell homeostasis and Zn(II) ion buffering.

    • Colette Whitfield
    Research Highlight
  • A geometrically constrained phosphine bearing a tridentate NNS pincer ligand can afford thermoneutral activation of N−H in ammonia.

    • Stacey-Lynn Paiva
    Research Highlight
  • The kinetics of proton-coupled electron transfer during electrocatalytic oxygen reduction are optimized when hydrogen bonding between reaction intermediates and ionic liquids coating the catalyst is maximized.

    • Ronghuan Zhang
    Research Highlight
  • Hydrogen-bonded organic frameworks can be employed to encapsulate protein therapeutics for enhanced cell uptake and intracellular biocatalysis.

    • Colette Whitfield
    Research Highlight