Research Highlights

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  • A rearrangement reaction — a classic of traditional organic synthesis — has been applied to a polymer, enabling conversion of a polyester to a vinyl polymer.

    • Stephen G. Davey
    Research Highlight
  • Cyanuric acid (CA) derivatives can co-assemble with polyadenine sequences to form a triple helical DNA-based structure bearing functional groups able to guide higher ordered architectures.

    • Colette Whitfield
    Research Highlight
  • Using ammonium bicarbonate as an additive can boost the reactivity of amines with carbon dioxide in microdroplet reactions.

    • Stacey-Lynn Paiva
    Research Highlight
  • Rapidly alternating the polarity of electrodes offers a new opportunity for synthetic chemists to obtain selective reaction outcomes in organic electrosynthesis.

    • Stephen G. Davey
    Research Highlight
  • A silicon-linker that tethers a diyne and a diynophile provides new mechanistic insight and control of hexadehydro-Diels–Alder (HDDA) reactions.

    • Colette Whitfield
    Research Highlight
  • Synthetic siderophore-antibiotic conjugates can afford promising antibiotic profiles against ESKAPE pathogens and unique resistant mechanisms.

    • Stacey-Lynn Paiva
    Research Highlight
  • The combination of mass spectroscopy-based proteomics with molecular dynamics enables the in-depth study of metallothioneine-Zn(II) binding mechanisms, critical to cell homeostasis and Zn(II) ion buffering.

    • Colette Whitfield
    Research Highlight
  • A geometrically constrained phosphine bearing a tridentate NNS pincer ligand can afford thermoneutral activation of N−H in ammonia.

    • Stacey-Lynn Paiva
    Research Highlight
  • The kinetics of proton-coupled electron transfer during electrocatalytic oxygen reduction are optimized when hydrogen bonding between reaction intermediates and ionic liquids coating the catalyst is maximized.

    • Ronghuan Zhang
    Research Highlight
  • Hydrogen-bonded organic frameworks can be employed to encapsulate protein therapeutics for enhanced cell uptake and intracellular biocatalysis.

    • Colette Whitfield
    Research Highlight
  • Homochiral porous cage-in-cage structures that self-assemble from lanthanide cations and chiral amino acid-derived ligands have been prepared and shown to be highly effective in enantioselective separations of small-molecule guests.

    • Peter W. Seavill
    Research Highlight
  • The supramolecular assembly of oligomers encoded with complementary recognition units enables duplex hybridization with helical structure.

    • Colette Whitfield
    Research Highlight
  • Selective cross-coupling at either of two similar halide substituents in a dihalogenated substrate can be achieved by controlling the speciation of the active palladium catalyst.

    • Jamal A. Malik
    Research Highlight
  • It has so far proved difficult to characterize halogen bonds in solution. A new and simple approach is to use scalar coupling between atoms in a halogen bond donor as a measure of bond strengths with diverse acceptors.

    • David Schilter
    Research Highlight
  • Locally activating prodrugs through targeted irradiation — a new concept for concurrent chemotherapy and radiotherapy.

    • Colette Whitfield
    Research Highlight
  • A polymer coating made from cosmetics-based ingredients can be applied to diverse surfaces to capture airborne droplets and mitigate the transmission of infectious respiratory diseases.

    • Claire Ashworth
    Research Highlight
  • A disilagermirene is a cyclopropene analogue with an unsaturated Si=Ge moiety. Such rings can be generated and stabilized in the presence of Ni, which the Si=Ge group binds through its σ-bond rather than π-bond.

    • David Schilter
    Research Highlight
  • A deep dive into the mechanism of a classic photoredox reaction.

    • Stephen G. Davey
    Research Highlight
  • Laser ablation enables the study of discrete metal difluorides and their reactions with dioxygen and ozone. Metal-fluoride vibrational energies give an indication of the charge on a metal difluoride moiety and help us rationalize the resultant structures.

    • David Schilter
    Research Highlight
  • A range of aryl and alkenyl organosodium reagents can be prepared by halogen–sodium exchange reactions with neopentylsodium and may be a useful alternative to widely used organolithium reagents.

    • Stephen G. Davey
    Research Highlight