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A model of autoimmune pancreatitis is developed by blocking the activation of NF-κB in pancreatic stellate cells, via conditional deletion of NEMO (IKKγ), which presents strong pancreatic inflammation with eosinophilia after the induction of chronic pancreatitis by repeated caerulein challenges.
Structural analyses of a Streptomyces viridochromogenes product template (PT) domain suggests molecular and functional similarities with known fungal PTs involved in polyketide synthase activity.
High temperatures lead to DNA double-strand break accumulation and asynapsis that trigger the meiotic checkpoint and apoptosis of spermatocytes in ex vivo cultures, providing a rationale for the heat sensitivity of sperm production in mammals.
Spider-silk protein increases the solubility of an aggregation-prone reporter protein, showing potential applications in controlling aggregation of disease-associated proteins by natural solubility domains.
Single-cell RNA-sequencing and chromatin accessibility analysis reveal transcriptomic and epigenomic changes between healthy patients and those affected by the systemic autoimmune disorder Vogt-Koyanagi-Harada disease.
PepNN integrates an attention-based deep learning module with transfer learning to predict the peptide binding sites of input proteins and the binding ability of proteins lacking a known peptide ligand.
An automated amplification-free digital RNA detection platform using CRISPR-Cas13a and magnetic bead technology implemented in a microchamber device demonstrates sensitive SARS-CoV-2 genomic RNA detection and variant discrimination.
A fluorescent probe for detecting membrane protein binding and remodeling events is presented, which relies on split-GFP technology to generate circularized nanodiscs useful in membrane protein biophysics and structural biology.
Telomeric-associated long non-coding RNAs TERRA and TERC can be quantified in culture cell lines and human PBMCs using peptide nucleic acid probes with flow cytometry (RNA-Flow).
Nsun4-mediated m5C and Mettl3-mediated m6A are found to be required for Sox9-regulated chondrogenic differentiation, whereby Nsun4 and Mettl3 interact with each other and recruit Ythdf2 and eEF1a-1 to form a complex at the 3’UTR of Sox9.
Proline utilization A (PutA) is a global transcriptional regulator besides its known role in proline oxidation, responding to its substrate and cofactors to coordinate between bacterial physiology and pathogenicity.
Arctic microalgae show specific adaptation to cold saline arctic conditions with differential expression of several antifreeze proteins, an ice-binding protein and an acyl-esterase involved in cold adaptation.
Transgenic plants expressing both Ve1 and Ve2 conferred enhanced signaling and disease resistance in susceptible potato in a race-specific manner, a step forward in generating disease resistant plants against Verticillium.
Brain patterns measured while participants first watched a movie in the fMRI scanner, then recalled the movie’s key narrative features, demonstrate that temporal compression in individuals’ retelling of past events predicts encoding-to-recall transformations.
Arctic ground squirrels hibernating in darkness activate the pars tuberalis - hypothalamus thyroid hormone signaling pathway, remodel hypothalamic tanycytes, and activate the reproductive axis.
Mice with breast cancer driven by mutations upstream of the PI3K/Akt insulin signaling pathway are found to be responsive to dapagliflozin, while those driven by mutations downstream of PI3K/Akt or in pathways with other driver mutations did not.
