Climate-induced forest dieback increases the risk of catastrophic loss of rare insect species

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  • Paul Schmidt Yáñez
  • Carlos Lopez-Vaamonde
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    Dr. Markus Löffler is a research group leader and physician-scientist at the University of Tübingen in Germany. His work is geared toward translational research with a focus on the characterization of HLA-presented peptides. Read more about his research and why, for him, "quality in peer-review generally supersedes speed.” Image credit: Verena Müller / University Hospital Tübingen

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  • Tumour spheroid experiments with real-time fluorescent ubiquitination-based cell cycle imaging are interpreted using mathematical modelling and statistical identifiability analysis. A framework is provided to compare data obtained across different experimental designs and the experimental design choices that provide reliable biological insight are revealed.

    • Ryan J. Murphy
    • Alexander P. Browning
    • Matthew J. Simpson
    Article Open Access
  • Verschueren et al. expand our understanding of the Stiles-Crawford effect in mammals by using super-high resolution expansion microscopy of the adult macaque eye. They show that cone photoreceptors have a planar polarity organized radially around the optical center of the eye and that Usher proteins establish a mechanical continuity between the outer and inner segments, which sheds light on the Stiles-Crawford effect in this species.

    • Anna Verschueren
    • Leyna Boucherit
    • José-Alain Sahel
    Article Open Access
  • Murray et al. present a multiplexed fluorescence-based immunohistochemistry approach and use it to screen up to 100 protein markers in the human olfactory bulb from neurologically healthy, Alzheimer’s, and Parkinson’s disease patients. In doing so, they identify differentially expressed biomarkers in Alzheimer’s, and Parkinson’s disease.

    • Helen C. Murray
    • Kory Johnson
    • Dragan Maric
    Article Open Access
  • The DsbD protein is normally required for cytochrome c maturation (Ccm) in bacteria. With cytochrome c-rich Shewanella oneidensis as the research model, NapB, the small subunit of the nitrate reductase which is a cytochrome c per se, was found to suppress the Ccm defect resulting from DsbD loss under anaerobic conditions.

    • Kailun Guo
    • Xue Feng
    • Haichun Gao
    Article Open Access
  • Mitotic divisions achieve equal re-partition of chromosomes into daughter cells. In their recent work in Developmental Cell, Sen, Harrison et al. propose that the risk of mis-segregation in human mitotic cells is higher than previously thought and identify the existence of an early-anaphase correction mechanism. The study documents kinetochore dynamics in unprecedented detail, providing a detailed look at the events preceding loss of correct chromosomal numericity and genomic stability.

    • Manuel Breuer
    Research Highlight Open Access
  • Dr. Aparna Bhaduri is an Assistant Professor at the University of California, Los Angeles (UCLA). Dr. Bhaduri received her PhD in 2016 from Stanford University, and completed a post-doctoral research fellowship at the University of California, San Francisco, before starting her independent research career at UCLA. In this Q&A, Dr. Bhaduri tells us about her current work, the joys and challenges of starting a lab during a pandemic, and recent advances in developmental neuroscience.

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  • In recognition of LGBTQ+ STEM Day on November 18th, we celebrate the achievements of queer researchers and their efforts to improve representation in STEM. Scott Cocker and Kyle Shanebeck are PhD students at the University of Alberta and co-founders of Scientific QUEERies, a biweekly seminar series that provides a platform for queer STEM professionals to share their achievements and personal stories. In this Q&A, we asked Scott and Kyle about their own research experiences, what it means to be queer in STEM, and the importance of initiatives like Scientific QUEERies.

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  • Aposematism is a prey strategy to communicate toxicity or danger to predators, often through bright colours, and over time is learned by predators. McLellan et al. report in Current Biology that association between an aposematic insect and its host plant is learned by wild birds, to the point that any insect on the plant faces a lower predation risk.

    • Luke R. Grinham
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  • In the 1930s, philosopher John Dewey stated: “We do not learn from experience… we learn from reflecting on experience.” The question of how we learn from the consequences of our actions has been investigated for decades. When deliberating between options, it is assumed that the outcome of our choice is used as a feedback signal to learn the value of the chosen option. But what about the forgone alternative? In a recent paper, Biderman and Shohamy show that we also revise the valuation of forgone options, assuming them to be inversely related to that of chosen ones.

    • Sophie Bavard
    • Stefano Palminteri
    Research Highlight Open Access

Centrosomes and Cilia

Centrosomes, the main microtubule-organizing centers in animal cells, orchestrate cell division and the building of cilia, which carry out a wide array of sensory and motile functions. Here, our Editorial Board Member Tiago Dantas and the in-house editors present a collection of articles published in Communications Biology that highlight the roles of these vital organelles.
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