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Supporting innovative research into the human microbiome
Researchers are embracing the gut microbiome. Our microflora do more than keep the intestines in check, they also affect our immune system and mental health. These new grants support investigators exploring the microbiome’s influence.
We warmly congratulate the three 2020 recipients of the Global Grants for Gut Health, which support studies seeking to elucidate unexplored host–microbe communication pathways and develop new strategies for preventing metabolic diseases and functional gastrointestinal disorders.
Guido Hooiveld’s proof-of-concept study, examining how the small-intestine microbiota influences different blood glucose responses when people eat the same foods, will be enabled by his Global Grant for Gut Health.
Marco Jost will use small-intestine organoids and his expertise in RNA sequencing and CRISPR technologies to study host–microbiome molecular communication. He will examine how these interactions might influence the physiology of other organs.
With his Global Grant for Gut Health, Purna Kashyap plans to create the first humanized mouse model of the small intestine to determine its role in modulating intestinal physiology and influencing gastrointestinal disease symptoms.
Introducing the projects that aim to elucidate the role of protists in food sensitivity, identify novel bioactives to prevent or reduce inflammatory bowel disease (IBD), and look for antibody–antigen interactions in microbiome-related diseases.
Adding to research focused on the overall composition of the gut microbiome, biologist Isabel Gordo will use her Global Grant for Gut Health to explore the evolutionary path of one common gut bacterium, Escherichia coli, inside living animals.
After many years studying the gastrointestinal tract, pharmacologist and senior physiology lecturer Niall Hyland will use his Global Grant for Gut Health to examine how the microbiome influences the ability to metabolise anti-depressant or anti-psychotic drugs.