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Targeting VEGF-induced vascular permeability

Blood vascular leakage in conjunction with stroke causes edema and a worsened outcome. Through augmented and selective tyrosine phosphatase activity, endothelial junctions can be sealed, resulting in reduced stroke volume and improved survival.

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Fig. 1: DEP1 dephosphorylation of VEGFR2 Y951 suppresses vascular permeability in stroke.


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The authors acknowledge support from the Swedish Cancer foundation and the Knut and Alice Wallenberg foundation.

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Correspondence to Mark Richards or Lena Claesson-Welsh.

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The authors declare no competing interests.

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Richards, M., Claesson-Welsh, L. Targeting VEGF-induced vascular permeability. Nat Cardiovasc Res 1, 413–414 (2022).

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