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VASCULAR BIOLOGY

Targeting VEGF-induced vascular permeability

Nature Cardiovascular Research volume 1, pages 413–414 (2022)Cite this article

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Blood vascular leakage in conjunction with stroke causes edema and a worsened outcome. Through augmented and selective tyrosine phosphatase activity, endothelial junctions can be sealed, resulting in reduced stroke volume and improved survival.

Blood vessels are in continuous exchange with their surrounding tissues. Fluids, molecules and cells pass between the endothelial cells that line the vessel lumen, at specific anatomical locations in the vascular tree. Macromolecules leak into tissues when endothelial cells in capillaries and venules, with a slow blood flow rate, are exposed to vascular endothelial growth factor (VEGF) or inflammatory cytokines1. Acute or persistent leakage of macromolecules in stroke, myocardial infarction, retinopathies and cancer worsen the disease process2. Suppressed VEGF-regulated leakage without interference with blood supply has been achieved in mouse models by genetic inactivation of key molecules in the leakage process3. However, therapeutic tools to specifically suppress macromolecular leakage have been missing. In this issue of Nature Cardiovascular Research, Corti et al. identify a strategy to specifically suppress leakage in a mouse stroke model that significantly decreases stroke volume and improves survival in mice, regardless of whether the treatment is applied to prevent or treat stroke4.

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Fig. 1: DEP1 dephosphorylation of VEGFR2 Y951 suppresses vascular permeability in stroke.

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Acknowledgements

The authors acknowledge support from the Swedish Cancer foundation and the Knut and Alice Wallenberg foundation.

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Authors and Affiliations

  1. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

    Mark Richards & Lena Claesson-Welsh

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  1. Mark Richards
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  2. Lena Claesson-Welsh
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Correspondence to Mark Richards or Lena Claesson-Welsh.

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The authors declare no competing interests.

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Richards, M., Claesson-Welsh, L. Targeting VEGF-induced vascular permeability. Nat Cardiovasc Res 1, 413–414 (2022). https://doi.org/10.1038/s44161-022-00066-0

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  • DOI: https://doi.org/10.1038/s44161-022-00066-0

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