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From mechanistic insight towards clinical implementation using normative modeling

Normative modeling is considered one of the most promising avenues towards personalized medicine. The integration of multimodal, mechanistic and lifespan modeling will play an essential role, but significant challenges need to be overcome before this promise can be turned into reality.

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Fig. 1: Conceptual overview of normative modeling and proposed extensions.


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This study was supported by the Deutsche Forschungsgemeinschaft (DFG), SCHW 1768/1-1 and the German Federal Ministry of Education and Research (BMBF, grants 01KU1905A and 01ZX1904A).

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Correspondence to Emanuel Schwarz.

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The authors declare no competing interests.

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Nature Computational Science thanks Richard Bethlehem and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Rieg, T., Schwarz, E. From mechanistic insight towards clinical implementation using normative modeling. Nat Comput Sci 2, 278–280 (2022).

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