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Bispecific antibodies seek out colon cancer stem cells

Patients with KRAS-mutant colorectal cancers do not respond to cetuximab, a monoclonal antibody against EGFR. A new proof-of-concept study presents a bispecific antibody with the ability to trigger EGFR degradation in LGR5+ cancer stem cells, and robust anti-tumor activity in KRAS-mutant and wild-type colorectal cancers.

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Fig. 1: A bispecific antibody that specifically triggers EGFR degradation in LGR5+ colorectal CSCs.


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Correspondence to Ömer H. Yilmaz.

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O.H.Y. is a member of the scientific advisory board of AVA Therapeutics.

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Goto, N., Yilmaz, Ö.H. Bispecific antibodies seek out colon cancer stem cells. Nat Cancer 3, 379–380 (2022).

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