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A cautionary tale from the machine scientist

Machine reading and knowledge extraction methods can be used to mine the scientific literature and reveal the direction and robustness of discoveries. Such efforts now point to the importance of independent tests of reported claims.

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Fig. 1: Enlightenment salon.

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  1. Belikov, A. V., Rzhetsky, A. & Evans, J. Nat. Mach. Intell. (2022).

    Article  Google Scholar 

  2. King, R. et al. Nature 427, 247–252 (2004).

    Article  Google Scholar 

  3. Schmidt, M. & Lipson, H. Science 324, 81–85 (2009).

    Article  Google Scholar 

  4. Evans, J. & Rzhetsky, A. Science 329, 399–400 (2010).

    Article  Google Scholar 

  5. Guimerà, R. et al. Sci. Adv. 6, eaav6971 (2020).

    Article  Google Scholar 

  6. Goodman, S. N., Fanelli, D. & Ioannidis, J. P. A. Sci. Transl. Med. 8, 341ps12 (2016).

    Article  Google Scholar 

  7. Nissen, S. B., Magidson, T., Gross, K. & Bergstrom, C. T. eLife 5, e21451 (2016).

    Article  Google Scholar 

  8. Stoeger, T., Gerlach, M., Morimoto, R. I. & Amaral, L. A. N. PLoS Biol. 16, e2006643 (2018).

    Article  Google Scholar 

  9. Danchev, V., Rzhetsky, A. & Evans, J. A. eLife 8, e43094 (2019).

    Article  Google Scholar 

  10. Lemaitre, B. FEBS J. 284, 875–882 (2017).

    Article  Google Scholar 

  11. Amaral, L. A. N. (2019).

  12. Alberts, B., Kirschner, M. W., Tilghman, S. & Varmus, H. Proc. Natl. Acad. Sci. USA 111, 5773–5777 (2014).

    Article  Google Scholar 

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Correspondence to Luís A. Nunes Amaral.

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Amaral, L.A.N. A cautionary tale from the machine scientist. Nat Mach Intell 4, 416–417 (2022).

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