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Periodic fasting prevents fat penalties in females

The fasting-mimicking diet is a five-day cycle of near total fasting each month that extends healthspan in male mice. In this issue of Nature Metabolism, Mishra et al. demonstrate life-extending and cardioprotective benefits of the fasting-mimicking diet in middle-aged female mice that are consuming a high-fat diet.

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Fig. 1: Fasting-mimicking diet extends life and health span in female mice that are fed a high fat diet.

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Correspondence to Leonie K. Heilbronn.

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Heilbronn, L.K. Periodic fasting prevents fat penalties in females. Nat Metab 3, 1282–1283 (2021). https://doi.org/10.1038/s42255-021-00472-x

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