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Embryogenesis without CTCF in flies and vertebrates

CTCF is a conserved DNA- and RNA-binding protein with roles in genome folding and transcriptional regulation. Two recent studies investigated how CTCF knockout perturbs genome biology and derails embryogenesis in zebrafish and Drosophila melanogaster, revealing contrasting effects across species.

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Fig. 1: Diagram of reported and potential impacts of CTCF on development.

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Correspondence to Geoffrey Fudenberg or Elphège P. Nora.

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Fudenberg, G., Nora, E.P. Embryogenesis without CTCF in flies and vertebrates. Nat Struct Mol Biol 28, 774–776 (2021). https://doi.org/10.1038/s41594-021-00662-x

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