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Outlining the proton-conduction pathway in otopetrin channels

New structural work sheds light on the architecture of otopetrin channels, offering insights into the mechanisms for proton permeation in this family.

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Fig. 1: Architecture and solvated pathways of Otop channels.
Fig. 2: Localization of key residues on a structural model of zOtop1.


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Supported by grants from the Gustafsson Foundation and Science for Life Laboratory.

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Correspondence to Lucie Delemotte.

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Delemotte, L. Outlining the proton-conduction pathway in otopetrin channels. Nat Struct Mol Biol 26, 528–530 (2019).

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