Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Inching closer to precision treatment for rheumatoid arthritis

Biopsies from synovial joints — and the abundance of B cells and macrophages therein — may instruct more effective treatment decisions for individuals with rheumatoid arthritis.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Cell types in rheumatoid arthritis-affected joints may guide more effective treatment decisions.


  1. Smolen, J. S. et al. Nat. Rev. Dis. Primers 4, 18001 (2018).

    Article  Google Scholar 

  2. Fraenkel, L. et al. Arthritis Care Res. 73, 924–939 (2021).

    Article  Google Scholar 

  3. Pitzalis, C., Choy, E. H. S. & Buch, M. H. Nat. Rev. Rheumatol. 16, 590–599 (2020).

    Article  Google Scholar 

  4. Donlin, L. T. et al. Nat. Rev. Rheumatol. 15, 327–399 (2019).

    Article  Google Scholar 

  5. Rivellese, F. et al. Nat. Med. (2022).

    Article  PubMed  Google Scholar 

  6. Humby, F. et al. Lancet 397, 305–317 (2021).

    CAS  Article  Google Scholar 

  7. Bykerk, V. & Emry, P. Arthritis Rheum. 62, 3519–3521 (2010).

    Article  Google Scholar 

  8. Burmester, G. R. & Pope, J. E. Lancet 389, 2338–2348 (2017).

    Article  Google Scholar 

  9. Aletaha, D. & Smolen, J. S. JAMA 320, 1360–1372 (2018).

    Article  Google Scholar 

  10. Zhang, F. et al. Preprint at bioRxiv (2022).

  11. Alivernini, S. et al. Nat. Med. 26, 1295–1306 (2020).

    CAS  Article  Google Scholar 

  12. Kuo, D. et al. Sci. Transl. Med. 11, eaau8587 (2019).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Laura T. Donlin.

Ethics declarations

Competing interests

L.T.D. is a member of the NIH-industry sponsored Accelerating Medicines Partnership consortium.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Donlin, L.T. Inching closer to precision treatment for rheumatoid arthritis. Nat Med 28, 1129–1131 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing