Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

ANTIMICROBIAL RESISTANCE

Tracing the origins of antibiotic resistance

Antibiotic resistance genes evolve in the environment, in animals, and in humans; strategic action is needed on all three fronts to help understand resistance and to limit its spread.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Antimicrobial resistance genes and resistant bacteria are continuously exchanged between humans, animals and the environment.

References

  1. Larsen, J. et al. Nature 602, 135–141 (2022).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. Ubukata, K. et al. J. Bacteriol. 171, 2882–2885 (1989).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  3. García-Álvarez, L. et al. Lancet Infect. Dis. 11, 595–603 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Lozano, C. et al. Microorganisms 8, 1615 (2020).

    CAS  Article  PubMed Central  Google Scholar 

  5. D’Costa, V. M. et al. Nature 477, 457–461 (2011).

    Article  PubMed  Google Scholar 

  6. D’Andrea, M. M. et al. Int. J. Med. Microbiol. 303, 305–317 (2013).

    Article  PubMed  Google Scholar 

  7. Harkins, C. P. et al. Genome Biol. 18, 130 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Wu, S. et al. Microb. Drug Res. 2, 435–441 (1996).

    CAS  Article  Google Scholar 

  9. van Loo, I. et al. Emerg. Infect. Dis. 13, 1834–1839 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Price, L. B. et al. mBio 3, e00305-11 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kinross, P. et al. Euro Surveill. 22, 16-00696 (2017).

    Article  PubMed Central  Google Scholar 

  12. Spoor, L. E. et al. mBio 4, e00356–13 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christina M. J. E. Vandenbroucke-Grauls.

Ethics declarations

Competing interests

Thea authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vandenbroucke-Grauls, C.M.J.E., Kluytmans, J.A.J.W. Tracing the origins of antibiotic resistance. Nat Med 28, 638–640 (2022). https://doi.org/10.1038/s41591-022-01752-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-022-01752-z

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing