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CANCER THERAPY

A probiotic supplement boosts response to cancer immunotherapy

Patients with kidney cancer who took probiotic supplements of Clostridium butyricum had improved response to immunotherapy, according to a randomized phase 1 study.

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Fig. 1: First randomized phase 1 trial combining a probiotic strain (C. butyricum CBM588) with a nivolumab plus ipilimumab regimen in metastatic kidney cancer.

References

  1. Mountzouris, K. C., McCartney, A. L. & Gibson, G. R. Br. J. Nutr. 87, 405–420 (2002).

    CAS  PubMed  Google Scholar 

  2. Isa, K. et al. Hum. Exp. Toxicol. 35, 818–832 (2016).

    CAS  Article  PubMed  Google Scholar 

  3. Dizman, N. et al. Nat. Med. https://doi.org/10.1038/s41591-022-01694-6 (2022).

    Article  PubMed  Google Scholar 

  4. Seki, H. et al. Pediatr. Int. 45, 86–90 (2003).

    Article  PubMed  Google Scholar 

  5. Stoeva, M. K. et al. Gut Microbes 13, 1–28 (2021).

    Article  PubMed  Google Scholar 

  6. Tomita, Y. et al. Cancer Immunol. Res. 8, 1236–1242 (2020).

    CAS  Article  PubMed  Google Scholar 

  7. Sivan, A. et al. Science 350, 1084–1089 (2015).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. Thana, M. et al. Clin. Genitourin. Cancer https://doi.org/10.1016/j.clgc.2021.12.003 (2021).

  9. Derosa, L. et al. Eur. Urol. 78, 195–206 (2020).

    CAS  Article  PubMed  Google Scholar 

  10. Salgia, N. J. et al. Eur. Urol. 78, 498–502 (2020).

    CAS  Article  PubMed  Google Scholar 

  11. Spencer, C. N. et al. Science 374, 1632–1640 (2021).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  12. Derosa, L. et al. Cancer Discov. 11, 2396–2412 (2021).

    CAS  Article  PubMed  Google Scholar 

Download references

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Correspondence to Lisa Derosa.

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L.D. declares consulting and advisory role fees from BMS, Sanofi, Astra Zeneca and was supported by Philantropia Fondation Gustave Roussy. L.Z. received research contract from Kaleido, Innovate Pharma and Pilege.

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Derosa, L., Zitvogel, L. A probiotic supplement boosts response to cancer immunotherapy. Nat Med 28, 633–634 (2022). https://doi.org/10.1038/s41591-022-01723-4

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  • DOI: https://doi.org/10.1038/s41591-022-01723-4

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