Extrathymic MHCII+Rorc+ Aire-expressing cells that share characteristics with type 3 innate lymphoid cells (ILC3s) internalize C. albicans and present its antigens, priming the development of Candida-specific TH17 cells.
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This work was supported by the Division of Intramural Research of the NIAID (ZIA AI001175 to M.S.L.).
The authors declare no competing interests.
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Oikonomou, V., Lionakis, M.S. Extrathymic Aire primes Candida-specific TH17 cells. Nat Immunol 23, 997–999 (2022). https://doi.org/10.1038/s41590-022-01252-9