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When inflammation turns sour on T cells

Inflamed tissue has a special milieu, with hypoxia, high levels of metabolites from anaerobic glycolysis, and acidosis. Stimulation of a proton-activated receptor, TDAG8 (GPR65), in T cells has an important role in inflammatory bowel disease by balancing pro- and anti-inflammatory signals.

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Fig. 1: Proton-activated receptors acting in inflammatory bowel disease.


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Work in the laboratory of the authors has been supported by the Swiss National Science Foundation (SNSF) and the SNSF-funded National Center for Competence in Research NCCR Kidney.CH.

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Correspondence to Carsten A. Wagner.

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C.A.W. has received honoraria from Ardelyx, Kyowa Kirin, Salmon Pharma, Advicenne and Medice not related to the work discussed here. P.H.I.S. has no competing interests.

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Wagner, C.A., Imenez Silva, P.H. When inflammation turns sour on T cells. Nat Immunol 23, 991–993 (2022).

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