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Resident T cells seek the perfect place to work from home

CD8+ resident memory T (TRM) cells from different tissues form a heterogeneous population. Transforming growth factor (TGF)-β-independent CD103 TRM cells in the liver retain the ability to move to barrier tissues or return to secondary lymphoid organs.

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Fig. 1: Liver TRM cells possess the ability to relocate to the skin to become TGF-β-dependent TRM cells.


  1. Behr, F. M., Chuwonpad, A., Stark, R. & van Gisbergen, K. P. J. M. Front. Immunol. 9, 1770 (2018).

    Article  Google Scholar 

  2. Christo, S. N. et al. Nat. Immunol. (2021).

    Article  PubMed  Google Scholar 

  3. Fernandez-Ruiz, D. et al. Immunity 45, 889–902 (2016).

    CAS  Article  Google Scholar 

  4. Mackay, L. K. et al. Science 352, 459–463 (2016).

    CAS  Article  Google Scholar 

  5. Mackay, L. K. et al. Immunity 43, 1101–1111 (2015).

    CAS  Article  Google Scholar 

  6. Milner, J. J. et al. Nature 552, 253–257 (2017).

    CAS  Article  Google Scholar 

  7. Gebhardt, T. et al. Nat. Immunol. 10, 524–530 (2009).

    CAS  Article  Google Scholar 

  8. Mackay, L. K. et al. Nat. Immunol. 14, 1294–1301 (2013).

    CAS  Article  Google Scholar 

  9. Fonseca, R. et al. Nat. Immunol. 21, 412–421 (2020).

    CAS  Article  Google Scholar 

  10. McNamara, H. A. et al. Sci. Immunol. 2, eaaj1996 (2017).

    Article  Google Scholar 

  11. Van Braeckel-Budimir, N., Varga, S. M., Badovinac, V. P. & Harty, J. T. Cell Rep. 24, 3374–3382.e3 (2018).

    Article  Google Scholar 

  12. Low, J. S. et al. J. Exp. Med. 217, e20192291 (2020).

    CAS  Article  Google Scholar 

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Correspondence to Ian A. Cockburn.

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McNamara, H.A., Cockburn, I.A. Resident T cells seek the perfect place to work from home. Nat Immunol 22, 1076–1078 (2021).

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