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Optogenetics in the hot seat

Optogenetic and thermogenetic tools have been limited to applications for single-state control of cellular processes. A single-component optogenetic tool was found to act as both a temperature sensor and a photoreceptor, enabling multi-state control of developmental signaling.

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Fig. 1: A schematic representation of the BcLOV4 protein’s integration of both light and heat.


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Correspondence to Maxwell Z. Wilson.

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Wilson, M.Z. Optogenetics in the hot seat. Nat Chem Biol 18, 118–119 (2022).

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