The Dog Aging Project is a long-term longitudinal study of ageing in tens of thousands of companion dogs. The domestic dog is among the most variable mammal species in terms of morphology, behaviour, risk of age-related disease and life expectancy. Given that dogs share the human environment and have a sophisticated healthcare system but are much shorter-lived than people, they offer a unique opportunity to identify the genetic, environmental and lifestyle factors associated with healthy lifespan. To take advantage of this opportunity, the Dog Aging Project will collect extensive survey data, environmental information, electronic veterinary medical records, genome-wide sequence information, clinicopathology and molecular phenotypes derived from blood cells, plasma and faecal samples. Here, we describe the specific goals and design of the Dog Aging Project and discuss the potential for this open-data, community science study to greatly enhance understanding of ageing in a genetically variable, socially relevant species living in a complex environment.
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All dog research described here, including informed owner consent, is approved by the Texas A&M University Institutional Animal Care and Use Committee, under AUPs 2018-0401 CAM and 2018-0368 CAM. The DAP is supported by grant U19AG057377 from the National Institute on Aging, a part of the National Institutes of Health, and by private donations. We thank S. Moon for help in preparing figures.
The authors declare no competing interests.
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Creevy, K.E., Akey, J.M., Kaeberlein, M. et al. An open science study of ageing in companion dogs. Nature 602, 51–57 (2022). https://doi.org/10.1038/s41586-021-04282-9