Extended Data Fig. 3: During injury, TERTHigh acinar show enhanced repopulation compared with randomly marked acinar cells. | Nature

Extended Data Fig. 3: During injury, TERTHigh acinar show enhanced repopulation compared with randomly marked acinar cells.

From: Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis

Extended Data Fig. 3

a, Schema of cerulein-induced pancreatitis. b, Immunofluorescence analysis of TertCreER mice 30 days after cerulein injections. Tomato (red), Ki67 (green) and DAPI (blue) are shown. TERTHigh, Ki67+ positive cells (green arrow) and TERTLow, Ki67+ cells (orange arrows) are shown. c, Quantification of TERTHigh, Ki67+ and TERTLow, Ki67+ cells at indicated time points (n=5 mice) (mean ± SD). d, Schematic of L-Arginine induced pancreatitis. e, Immunofluorescence analysis of TertCreER mice 30 days after L-Arginine induced pancreatitis. f, Quantification of Tomato-positive cells per clone with and without injury (n=5 mice) (mean ± SD). Scale bars, 25µm (d), 250 µm (e). P values calculated by two-sided Mann-Whitney test (c, f).

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