Extended Data Fig. 6: DNA binding by CSB and transcription stimulation. | Nature

Extended Data Fig. 6: DNA binding by CSB and transcription stimulation.

From: Structural basis of human transcription–DNA repair coupling

Extended Data Fig. 6

a, CSB interactions with upstream DNA in pre-translocated state (structure 1). b, CSB interactions with upstream DNA in post-translocated state (structure 2). c, Scheme illustrating the movement of DNA during CSB-dependent ATPase activity. d, Comparison of models and cryo-EM densities for the pulling pin in the structure reported here and the yeast Pol II-Rad26 structure reported previously (PDB code 5VVR)19. e, Structure-based model for CSB stimulation by CSA due to restricting lobe 2 motion via CIM binding to CSA.

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