Extended Data Table 7 Inhibition of serine β-lactamases by ETX0462

From: Rational design of a new antibiotic class for drug-resistant infections

  1. Measurements of β-lactamase inhibition were performed as previously described7. Averages (± standard deviations) are shown where replicates exist. For TEM-1 and P. aeruginosa AmpC, one of the measurements showed weakly time-dependent inhibition, resulting in a value for kinact/Ki, and the other measurement showed no time-dependence of inhibition, resulting in a value for the equilibrium dissociation constant Ki.