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Measurements of β-lactamase inhibition were performed as previously described7. Averages (± standard deviations) are shown where replicates exist. For TEM-1 and P. aeruginosa AmpC, one of the measurements showed weakly time-dependent inhibition, resulting in a value for kinact/Ki, and the other measurement showed no time-dependence of inhibition, resulting in a value for the equilibrium dissociation constant Ki.