Extended Data Table 4 Antibacterial activity of Compound 2 and ETX0462 against an isogenic P. aeruginosa panel of strains overexpressing individual β-lactamases

From: Rational design of a new antibiotic class for drug-resistant infections

  1. MICs (mg/L) of comparator β-lactams, Compound 2 and ETX0462 versus PAO1ΔampCΔpoxB, a P. aeruginosa lab strain devoid of intrinsic β-lactamase activity, as compared to an isogenic panel of derivative strains, each of which individually overexpresses a single β-lactamase. Greater than two-dilution changes are considered phenotypically significant. Values shown are the mode of 3 biological replicates.