Extended Data Fig 3: Heat maps generated through supervised clustering by structure-function-based groups cluster drug sensitivity better than exon-based groups. | Nature

Extended Data Fig 3: Heat maps generated through supervised clustering by structure-function-based groups cluster drug sensitivity better than exon-based groups.

From: Structure-based classification predicts drug response in EGFR-mutant NSCLC

Extended Data Fig 3

a, b, Heat maps supervised clustering by exon-based (a) or structure-function-based (b) groups of log (Mutant/WT) ratios from Ba/F3 cells expressing indicated mutations after 72 h of indicated drug treatment. To determine the mutant/WT ratio, IC50 values for each drug and cell line were calculated and then compared to the average IC50 values of Ba/F3 cells expressing WT EGFR (+10ng/ml EGF to maintain viability). Squares are representative of the median of n=3 replicates. For co-occurring mutations, the order of mutations 1, 2, and 3 were assigned arbitrarily. Groups were assigned based on structural predictions

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