Fig. 5: EGFR mutations can be divided into four distinct subgroups. | Nature

Fig. 5: EGFR mutations can be divided into four distinct subgroups.

From: Structure-based classification predicts drug response in EGFR-mutant NSCLC

Fig. 5

Representative space-filling models of each EGFR subgroup demonstrate changes in overall shape of drug-binding pocket. The P-loop (blue), hinge region (ATP-binding site (orange)), hydrophobic cleft (green), and αC-helix (yellow) are shown. Red dots represent location of mutations. Arrows indicate location of structural changes compared with wild-type EGFR. The most common mutations are shown for each group, and drug sensitivity or selectivity is colour-coded and listed from most selective or sensitive (green) to resistant (red). PKCi, PKC inhibitor; ALKi, ALK inhibitor.

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