Fig. 1: Atypical EGFR mutations are associated with worse patient outcomes. | Nature

Fig. 1: Atypical EGFR mutations are associated with worse patient outcomes.

From: Structure-based classification predicts drug response in EGFR-mutant NSCLC

Fig. 1

a, Percentage of patients with NSCLC containing classical and atypical EGFR mutations (n = 11,619 patients). Classical EGFR mutations are L858R, T790M and various Ex19dels (Methods). b, Percentage of atypical EGFR mutations observed in patients with NSCLC (n = 7,199 mutations). Atypical EGFR mutations are defined as non-classical, non-synonymous mutations. c, Lollipop plot of frequency of atypical EGFR mutations in patients with NSCLC (n = 7,199 mutations). EGFR mutations associated with acquired drug resistance are highlighted in red. d, Kaplan–Meier plot of time to treatment failure (TTF) (time from TKI commencement until radiologic progression, discontinuation, or death) of patients with NSCLC tumours containing classical (n = 245 patients) or atypical (n = 109 patients) EGFR mutations after EGFR TKI treatment. e, Forest plot of HR calculated from Kaplan–Meier plots of patients with various subsets of atypical mutations or classical EGFR mutations. In d, e, HR and P value were calculated using two-sided Mantel–Cox log-rank tests. Data are HR ± 95% confidence interval. All atypical, n = 109; all atypical without Ex20ins, n = 97; exon 18, n = 29; exon 19, n = 22; exon 20, n = 41; exon 21, n = 18. NS, not significant.

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