Extended Data Fig. 10: Structure-function groups identify patients with greater benefit to 2nd-gen TKIs than exon-based groups. | Nature

Extended Data Fig. 10: Structure-function groups identify patients with greater benefit to 2nd-gen TKIs than exon-based groups.

From: Structure-based classification predicts drug response in EGFR-mutant NSCLC

Extended Data Fig. 10

a, b, Overall response rate to afatinib stratified by structure-function-based groups (N= 507: Classical-like N=91, T790M-like N=103, Ex20ins-L N=120, and PACC N=193) (a) or exon based groups (N= 528: Exon 18 N=133, Exon 19 N=22, Exon 20 N=294, Exon 21 N=79) (b). When mutations were not explicitly stated (N=21), those patients were excluded from the structure-function based analysis. c, Kaplan-Meier plot of duration of afatinib treatment of patients with NSCLC tumors harboring atypical EGFR mutations (N= 364 patients) stratified by exon-based groups. Exon 18 N=87, Exon 19 N=19, Exon 20 N=195, and Exon 21 N=63. d, Kaplan-Meier plot of TTF of patients with NSCLC harboring non-PACC atypical EGFR mutations (N= 56) treated with 1st- (N=25), 2nd- (N=13), or 3rd-gen (N=18) EGFR TKIs. Forrest plot comparing PACC and non-PACC mutants can be found in Fig. 4d. eh, Kaplan-Meier plots of TTF of patients atypical EGFR mutations stratified by EGFR TKI class for exons 18 (N=40) (e), 19 (N=19) (f), 20 (N=24) (g), and 21 (N=26) (h). Forrest plot comparing HRs and p-values across exons can be found in Fig. 4d.

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