This represents an alternative visualization to Fig. 1a that does not sample the data. It uses the recent PDB dataset (Methods), which is restricted to structures with a reported resolution of <3.5 Å (n = 2,756,569 residues). Residues were assigned to bins of width 10 based on their pLDDT (minimum, 20; maximum, 100). Markers show the mean lDDT-Cα within each bin, while the lDDT-Cα distribution is visualized as a Matplotlib violin plot (kernel density estimate bandwidth, 0.2). The smallest sample size for the corresponding violin is 5,655 residues for the left-most bin.