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The gene expression data used to generate the original H2014 paper is available at the Gene Expression Omnibus (GEO) under accession code GSE53195. The ALSPAC genotype data can be accessed via http://www.bristol.ac.uk/alspac/. This study makes use of data from dbGaP (accessions phs000428.v1.p1) and EGA (accessions EGAS00001000108 and EGAS00001000090) (see Supplementary Information for a full list of acknowledgements to these datasets).
Code is available at: https://github.com/explodecomputer/eqtl-2d.
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G.H. was funded by the Wellcome Trust and Royal Society (208806/Z/17/Z). J.E.P. is supported by National Health and Medical Research Council Fellowship (APP1175781). J.Y. and P.M.V. are supported by the Australian Research Council (DP160101343, DP160101056, FT180100186 and FL180100072) and the Australian National Health and Medical Research Council (1078037, 1078901, 1113400 and 1107258). J.Y. is supported by the Westlake Education Foundation. We are extremely grateful to all the families who took part in the ALSPAC study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses.
The authors declare no competing interests.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Hemani, G., Powell, J.E., Wang, H. et al. Phantom epistasis between unlinked loci. Nature 596, E1–E3 (2021). https://doi.org/10.1038/s41586-021-03765-z