Extended Data Fig. 6: STING drives neuroinflammation in Npc1−/− mice. | Nature

Extended Data Fig. 6: STING drives neuroinflammation in Npc1−/− mice.

From: Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

Extended Data Fig. 6

a, Immunoblot analysis of the indicated proteins (left) in whole-brain lysates from BALB/c Npc1+/+, Npc1−/− and Npc1−/−Sting1−/− mice (n = 2). b, qRT–PCR analysis of the expression of ISGs in the cerebellum of BALB/c Npc1+/+, Npc1−/− and Npc1−/−Sting1−/− mice (n = 4). c, Heat map showing the expression of ISGs in BMDMs from BALB/c Npc1+/+, Npc1−/− and Npc1−/−Sting1−/− mice (n = 3). The mRNA expression level of each ISG was measured by qRT–PCR. b, Data are mean ± s.d. Unpaired two-tailed Student’s t-test. Data are representative of at least two independent experiments.

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