Extended Data Fig. 12: Expression and prognostic effect of EGFR in patients with HCC. | Nature

Extended Data Fig. 12: Expression and prognostic effect of EGFR in patients with HCC.

From: EGFR activation limits the response of liver cancer to lenvatinib

Extended Data Fig. 12

ad, IHC staining analyses of EGFR were performed in 298 patients with HCC. The H-score method assigned a score of 0–300 to each patient sample, based on the percentage of cells stained at different intensities. The discriminatory threshold was set at 200. All samples were classified as low (H < 200; EGFRlow) or high (H ≥ 200; EGFRhigh) EGFR expression. a, Typical images of EGFRlow and EGFRhigh cases according to their H-score. Scale bars, 200 μm. b, Distribution of EGFR expression levels in 298 patients with HCC as represented by various H-score ranges. Out of 298 patients with HCC, 157 had H-score of H ≥ 200 (EGFRhigh). Kaplan–Meier analysis for overall survival (OS, c) and time to relapse (TTR, d) was performed according to EGFR levels. Statistical analysis by log-rank Mantel–Cox test. e, The CONSORT diagram shows the patient flow through the clinical trial. f, H&E and IHC analyses showing high EGFR expression in formalin-fixed paraffin embedded (patient IDs A–L) tissue sections from HCC. All of the biopsies were obtained from liver tumours when patients were diagnosed or treated with primary hepatectomy. Scale bars, 50 μm

Source data.

Back to article page