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Unravelling the pharmacogenomics of TNF inhibition

Despite the previous identification of genes involved in the treatment response to TNF inhibition in rheumatoid arthritis, no genetic biomarkers are currently used in clinical decision-making. Might the heterogeneous nature of the disease activity score, which is often used as the outcome measure in genetic studies, partly explain this gap?

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Correspondence to Marieke J. H. Coenen.

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Coenen, M.J.H. Unravelling the pharmacogenomics of TNF inhibition. Nat Rev Rheumatol 14, 689–690 (2018).

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