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STROKE

New role for enzyme autotaxin in stroke excitotoxicity

Nature Reviews Neurology volume 18, page 318 (2022)Cite this article

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Higher levels of the enzyme autotaxin (ATX) are associated with worse outcomes in individuals with stroke, says a new study published in Science Translational Medicine. In a mouse model of stroke, inhibition of ATX improved outcome, indicating therapeutic potential.

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Original article

  • Bitar, L. et al. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Sci. Transl. Med. 14, eabk0135 (2022)

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Sarah Lemprière

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  1. Sarah Lemprière
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Correspondence to Sarah Lemprière.

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Lemprière, S. New role for enzyme autotaxin in stroke excitotoxicity. Nat Rev Neurol 18, 318 (2022). https://doi.org/10.1038/s41582-022-00666-1

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  • DOI: https://doi.org/10.1038/s41582-022-00666-1

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