Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

OESOPHAGEAL CANCER

Toripalimab and chemotherapy in oesophageal squamous cell carcinoma

Nature Reviews Gastroenterology & Hepatology volume 19, page 280 (2022)Cite this article

Subjects

Toripalimab is a humanized monoclonal antibody to PD1. In a phase III trial, 514 patients with treatment-naive, advanced oesophageal squamous cell carcinoma from 72 centres in China were randomized to receive toripalimab or placebo, plus a chemotherapy regimen (paclitaxel plus cisplatin). The toripalimab group had a significant improvement in progression-free survival compared with the placebo group (HR 0.58; 95% CI 0.46–0.74; P < 0.0001). At interim analysis, overall survival was also significantly improved in the toripalimab group. The groups had comparable levels of severe treatment-related adverse effects (NCT03829969).

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

Original article

  • Wang, Z.-X. et al. Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): a multi-center phase 3 trial. Cancer Cell 40, 277–288 (2022)

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Jordan Hindson

Authors
  1. Jordan Hindson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jordan Hindson.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hindson, J. Toripalimab and chemotherapy in oesophageal squamous cell carcinoma. Nat Rev Gastroenterol Hepatol 19, 280 (2022). https://doi.org/10.1038/s41575-022-00615-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41575-022-00615-9

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing