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Gastric metaplasia could initiate the serrated neoplasia pathway in CRC

A subset of colorectal cancers arises from sessile serrated lesions. Tumorigenesis via the serrated neoplasia pathway is largely unexplored. Now, a new study suggests that this pathway is initiated by gastric metaplasia induced by damage and repair, which is triggered by disadvantageous composition of microbiota in the proximal colon.

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Fig. 1: Gastric metaplasia caused by microbial dysbiosis might initiate the serrated neoplasia pathway in colorectal cancer.


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Correspondence to Evelien Dekker.

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Competing interests

E.D. received a research grant from FujiFilm, honorarium for consultancy from FujiFilm, Olympus, GI Supply, CPP-FAP, PAION and Ambu, and speakers’ fees from Olympus, GI Supply, Norgine, IPSEN, PAION and FujiFilm. J.E.G.I. declares no competing interests.

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IJspeert, J.E.G., Dekker, E. Gastric metaplasia could initiate the serrated neoplasia pathway in CRC. Nat Rev Gastroenterol Hepatol 19, 217–218 (2022).

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