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COLORECTAL CANCER

Gastric metaplasia could initiate the serrated neoplasia pathway in CRC

Nature Reviews Gastroenterology & Hepatology volume 19, pages 217–218 (2022)Cite this article

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A subset of colorectal cancers arises from sessile serrated lesions. Tumorigenesis via the serrated neoplasia pathway is largely unexplored. Now, a new study suggests that this pathway is initiated by gastric metaplasia induced by damage and repair, which is triggered by disadvantageous composition of microbiota in the proximal colon.

Refers to Chen, B. et al. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 184, 6262–6280 (2021).

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Fig. 1: Gastric metaplasia caused by microbial dysbiosis might initiate the serrated neoplasia pathway in colorectal cancer.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands

    Joep E. G. IJspeert & Evelien Dekker

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  1. Joep E. G. IJspeert
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  2. Evelien Dekker
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Correspondence to Evelien Dekker.

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Competing interests

E.D. received a research grant from FujiFilm, honorarium for consultancy from FujiFilm, Olympus, GI Supply, CPP-FAP, PAION and Ambu, and speakers’ fees from Olympus, GI Supply, Norgine, IPSEN, PAION and FujiFilm. J.E.G.I. declares no competing interests.

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IJspeert, J.E.G., Dekker, E. Gastric metaplasia could initiate the serrated neoplasia pathway in CRC. Nat Rev Gastroenterol Hepatol 19, 217–218 (2022). https://doi.org/10.1038/s41575-022-00592-z

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  • DOI: https://doi.org/10.1038/s41575-022-00592-z

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